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Simulated Cell Division Processes of the Xenopus Cell Cycle Pathway by Genomic Object Net
Matsui, Mika ; Fujita, Sachie ; Suzuki, Shunichi ; Matsuno, Hiroshi ; Miyano, Satoru
Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)
Matsuno et al. modeled and simulated a Drosophila multicellular patterning by Delta-Notch signaling pathway by using a software "Genomic Object Net" which is developed based on hybrid functional Petri net (HFPN) architecture. However, in this model, cellular formation is fixed throughout the simulation. Then, this paper constructs an HFPN model of Xenopus cell cycle pathway which includes the mechanism for cell division control as well as checkpoint processes. With this model, dynamic cell division processes of Xenopus early embryo including the changes in cell division cycles from synchronous to asynchronous are simulated.
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