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Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)

In this paper we study the intrinsic noise effect on the switching behavior of a simple genetic circuit corresponding to the genetic toggle switch model. The numerical results obtained from a noisy mean-field model are compared to those obtained from the stochastic Gillespie simulation of the corresponding system of chemical reactions. Our results show that by using a two step reaction approach for modeling the transcription and translation processes one can make the system to lock in one of the steady states for exponentially long times.

DOI: 10.2390/biecoll-jib-2006-23

Andrecut, M. ; Kauffman, S. A.  (2006)  Noise in Genetic Toggle Switch Models. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 3(1), 2006

Online-Journal: http://journal.imbio.de/index.php?paper_id=23
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2007/204

Ralf Hofestädt, Thoralf Töpel (eds.). Integrative Bioinformatics -
Yearbook 2006. Shaker, 2007.

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