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Noise in Genetic Toggle Switch Models

Andrecut, M. ; Kauffman, S. A.

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)


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Abstract:
In this paper we study the intrinsic noise effect on the switching behavior of a simple genetic circuit corresponding to the genetic toggle switch model. The numerical results obtained from a noisy mean-field model are compared to those obtained from the stochastic Gillespie simulation of the corresponding system of chemical reactions. Our results show that by using a two step reaction approach for modeling the transcription and translation processes one can make the system to lock in one of the steady states for exponentially long times.


Institution: Faculty of Technology, Research Groups in Informatics
DDC classification: Data processing, computer science, computer systems

Suggested Citation:
Andrecut, M. ; Kauffman, S. A.  (2006)  Noise in Genetic Toggle Switch Models. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 3(1), 2006

Online-Journal: http://journal.imbio.de/index.php?paper_id=23
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2007/204

Also published by Shaker:
Ralf Hofestädt, Thoralf Töpel (eds.). Integrative Bioinformatics -
Yearbook 2006. Shaker, 2007.


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