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Noise in Genetic Toggle Switch Models
Andrecut, M. ; Kauffman, S. A.
Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)
In this paper we study the intrinsic noise effect on the switching behavior of a simple genetic circuit corresponding to the genetic toggle switch model. The numerical results obtained from a noisy mean-field model are compared to those obtained from the stochastic Gillespie simulation of the corresponding system of chemical reactions. Our results show that by using a two step reaction approach for modeling the transcription and translation processes one can make the system to lock in one of the steady states for exponentially long times.
||Faculty of Technology, Research Groups in Informatics
||Data processing, computer science, computer systems
Also published by Shaker:
Ralf Hofestädt, Thoralf Töpel (eds.). Integrative Bioinformatics -
Yearbook 2006. Shaker, 2007.