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Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)

Structural genomics projects are leading to the discovery of relationships between proteins that would not have been anticipated from consideration of sequence alone. However the assignment of function via structure remains difficult as some structures are compatible with a variety of functions. In this study we explore the relationships between structural diversity and functional diversity within distantly related members of SCOP superfamilies. We use the Gene Ontology functional classification scheme and Greens path entropy to measure functional diversity. We observe a negative correlation between the functional entropy of a superfamily and the size of the conserved core.

DOI: 10.2390/biecoll-jib-2006-46

Casbon, James ; Saqi, Mansoor  (2006)  Functional diversity within protein superfamilies. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 3(2), 2006. Special Issue: 3rd Integrative Bioinformatics Workshop, Harpenden, United Kingdom, 2

Online-Journal: http://journal.imbio.de/index.php?paper_id=46
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2007/227

Ralf Hofestädt, Thoralf Töpel (eds.). Integrative Bioinformatics -
Yearbook 2006. Shaker, 2007.

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