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Reconstruction of biological networks based on life science data integration

Kormeier, Benjamin ; Hippe, Klaus ; Arrigo, Patrizio ; Töpel, Thoralf ; Janowski, Sebastian ; Hofestädt, Ralf

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)



Abstract:
For the implementation of the virtual cell, the fundamental question is how to model and simulate complex biological networks. Therefore, based on relevant molecular database and information systems, biological data integration is an essential step in constructing biological networks. In this paper, we will motivate the applications BioDWH - an integration toolkit for building life science data warehouses, CardioVINEdb - a information system for biological data in cardiovascular-disease and VANESA- a network editor for modeling and simulation of biological networks. Based on this integration process, the system supports the generation of biological network models. A case study of a cardiovascular-disease related gene-regulated biological network is also presented.


Beteiligte Einrichtung: Technische Fakultät, Arbeitsgruppen der Informatik
DDC-Sachgruppe: Datenverarbeitung, Informatik

Zitat-Vorschlag:
Kormeier, Benjamin ; Hippe, Klaus ; Arrigo, Patrizio ; Töpel, Thoralf ; Janowski, Sebastian ; Hofestädt, Ralf  (2010)  Reconstruction of biological networks based on life science data integration. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 7(2), 2010

Online-Journal: http://journal.imbio.de/article.php?aid=146
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2010/5047



 Fragen und Anregungen an: publikationsdienste.ub@uni-bielefeld.de
 Letzte Änderung: 15.2.2011
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