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BN++ - A Biological Information System
Küntzer, Jan ; Blum, Torsten ; Gerasch, Andreas ; Backes, Christina ; Hildebrandt, Andreas ; Kaufmann, Michael ; Kohlbacher, Oliver ; Lenhof, Hans-Peter
Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)
Recent years have seen an explosive growth in the amount of biochemical data available. Numerous databases have been established and are being used as an essential resource by biologists around the world. The sheer amount and heterogeneity of these data poses a major challenge: data integration and, based thereupon, the integrative analysis of these data. We present BN++, the biochemical network library, a powerful software package for integrating, analyzing, and visualizing biochemical data in the context of networks. BN++ is based on a comprehensive and extensible object model (BioCore), which has been implemented as a C++ framework, a Java class library, and a relational database. The C++ framework is used to efficiently import, integrate, and analyze the data, which is stored in a data warehouse. The Java-based viewer (BiNA) provides a powerful platform-independent visualization of the data using sophisticated graph layout algorithms. Currently, the data warehouse imports and integrates data from about a dozen important databases including, among others, sequence data, metabolic and regulatory networks, and protein interaction data. We illustrate the usefulness of BN++ with a few select example applications. BN++ is open source software available from our website at http://www.bnplusplus.org.
||Faculty of Technology, Research Groups in Informatics
||Data processing, computer science, computer systems
Küntzer, Jan ; Blum, Torsten ; Gerasch, Andreas ; Backes, Christina ; Hildebrandt, Andreas ; Kaufmann, Michael ; Kohlbacher, Oliver ; Lenhof, Hans-Peter (2006
) BN++ - A Biological Information System.
Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 3(2), 2006. Special Issue: 3rd Integrative Bioinformatics Workshop, Harpenden, United Kingdom, 2
Also published by Shaker:
Ralf Hofestädt, Thoralf Töpel (eds.). Integrative Bioinformatics -
Yearbook 2006. Shaker, 2007.