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Functional diversity within protein superfamilies

Casbon, James ; Saqi, Mansoor

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)

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Structural genomics projects are leading to the discovery of relationships between proteins that would not have been anticipated from consideration of sequence alone. However the assignment of function via structure remains difficult as some structures are compatible with a variety of functions. In this study we explore the relationships between structural diversity and functional diversity within distantly related members of SCOP superfamilies. We use the Gene Ontology functional classification scheme and Greens path entropy to measure functional diversity. We observe a negative correlation between the functional entropy of a superfamily and the size of the conserved core.

Institution: Faculty of Technology, Research Groups in Informatics
DDC classification: Data processing, computer science, computer systems

Suggested Citation:
Casbon, James ; Saqi, Mansoor  (2006)  Functional diversity within protein superfamilies. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 3(2), 2006. Special Issue: 3rd Integrative Bioinformatics Workshop, Harpenden, United Kingdom, 2

Online-Journal: http://journal.imbio.de/index.php?paper_id=46
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2007/227

Also published by Shaker:
Ralf Hofestädt, Thoralf Töpel (eds.). Integrative Bioinformatics -
Yearbook 2006. Shaker, 2007.

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