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From MIN model to ordinary differential equations

Yartseva, A. ; Devillers, R. ; Klaudel, H. ; Kepes, F.

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)


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Abstract:
Biological interaction networks can be modeled using the Modular Interaction Network (MIN) formalism, which provides an intermediary modeling level between the biological and mathematical ones. MIN focuses on a simple but structured and versatile representation of biological knowledge, without targeting a particular analysis or simulation technique. In this paper, we propose a translation procedure which, starting from a MIN specification of a biological system, generates its representation in ordinary differential equations (ODEs) allowing to study the dynamics of the system. The translation is illustrated on a classical benchmark: the lambda phage genetic switch.


Institution: Faculty of Technology, Research Groups in Informatics
DDC classification: Data processing, computer science, computer systems

Suggested Citation:
Yartseva, A. ; Devillers, R. ; Klaudel, H. ; Kepes, F.  (2007)  From MIN model to ordinary differential equations. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 4(3), 2007. Special Issue: 4th Integrative Bioinformatics Workshop, Gent, Belgium

Online-Journal: http://journal.imbio.de/index.php?paper_id=61
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2007/242



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