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Functional and Transcriptional Coherency of Modules in the Human Protein Interaction Network

Futschik, Matthias E. ; Chaurasia, Gautam ; Tschaut, Anna ; Russ, Jenny ; Babu, M. Madan ; Herzel, Hanspeter

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)


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Abstract:
Modularity is a major design principle in interaction networks. Various studies have shown that protein interaction networks in prokaryotes and eukaryotes display a modular structure. A majority of the studies have been performed for the yeast interaction network, for which data have become abundant. The systematic examination of the human protein interaction network, however, is still in an early phase. To assess whether the human interaction network similarly displays a modular structure, we assembled a large protein network consisting of over 30,000 interactions. More than 670 modules were subsequently identified based on the detection of cliques. Inspection showed that these modules included numerous known protein complexes. The extracted modules were scrutinized for their coherency with respect to function, localization and expression, thereby allowing us to distinguish between stable and dynamic modules. Finally, the examination of the overlap between modules identified key proteins linking distinct molecular processes.


Institution: Faculty of Technology, Research Groups in Informatics
DDC classification: Data processing, computer science, computer systems

Suggested Citation:
Futschik, Matthias E. ; Chaurasia, Gautam ; Tschaut, Anna ; Russ, Jenny ; Babu, M. Madan ; Herzel, Hanspeter  (2007)  Functional and Transcriptional Coherency of Modules in the Human Protein Interaction Network. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 4(3), 2007. Special Issue: 4th Integrative Bioinformatics Workshop, Gent, Belgium

Online-Journal: http://journal.imbio.de/index.php?paper_id=76
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2007/257



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