Universität Bielefeld Electronic Collections animiertes Foto Universität Bielefeld

Zugang zum Dokument



Enhancing Data Integration with Text Analysis to Find Proteins Implicated in Plant Stress Response

Hassani-Pak, Keywan ; Legaie, Roxane ; Canevet, Catherine ; van den Berg, Hugo A. ; Moore, Jonathan D. ; Rawlings, Christopher J.

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)



Abstract:
High throughput genomic studies can identify large numbers of potential candidate genes, which must be interpreted and filtered by investigators to select the best ones for further analysis. Prioritization is generally based on evidence that supports the role of a gene product in the biological process being investigated. The two most important bodies of information providing such evidence are bioinformatics databases and the scientific literature. In this paper we present an extension to the Ondex data integration framework that uses text mining techniques over Medline abstracts as a method for accessing both these bodies of evidence in a consistent way. In an example use case, we apply our method to create a knowledge base of Arabidopsis proteins implicated in plant stress response and use various scoring metrics to identify key protein-stress associations. In conclusion, we show that the additional text mining features are able to highlight proteins using the scientific literature that would not have been seen using data integration alone. Ondex is an open-source software project and can be downloaded, together with the text mining features described here, from www.ondex.org.


Beteiligte Einrichtung: Technische Fakultät, Arbeitsgruppen der Informatik
DDC-Sachgruppe: Datenverarbeitung, Informatik

Zitat-Vorschlag:
Enhancing Data Integration with Text Analysis to Find Proteins Implicated in Plant Stress Response. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 7(3), 2010

Online-Journal: http://journal.imbio.de/article.php?aid=121
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2010/5021



 Fragen und Anregungen an: publikationsdienste.ub@uni-bielefeld.de
 Letzte Änderung: 15.2.2011
 Impressum
OPUS-Logo     OAI-zertifiziert      Universitätsbibliothek Bielefeld
OAI-Logo