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Noise tolerance of Multiple Classifier Systems in data integration-based gene function prediction

Rè, Matteo ; Valentini, Giorgio

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)


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Abstract:
The availability of various high-throughput experimental and computational methods developed in the last decade allowed molecular biologists to investigate the functions of genes at system level opening unprecedented research opportunities. Despite the automated prediction of genes functions could be included in the most difficult problems in bioinformatics, several recently published works showed that consistent improvements in prediction performances can be obtained by integrating heterogeneous data sources. Nevertheless, very few works have been dedicated to the investigation of the impact of noisy data on the prediction performances achievable by using data integration approaches. In this contribution we investigated the tolerance of multiple classifier systems (MCS) to noisy data in gene function prediction experiments based on data integration methods. The experimental results show that performances of MCS do not undergo a significant decay when noisy data sets are added. In addition, we show that in this task MCS are competitive with kernel fusion, one of the most widely applied technique for data integration in gene function prediction problems.


Institution: Faculty of Technology, Research Groups in Informatics
DDC classification: Data processing, computer science, computer systems

Suggested Citation:
Noise tolerance of Multiple Classifier Systems in data integration-based gene function prediction. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 7(3), 2010

Online-Journal: http://journal.imbio.de/article.php?aid=139
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2010/5039



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