Universität Bielefeld Electronic Collections animiertes Foto Universität Bielefeld

Access to the Document



Prognostic Prediction through Biclustering-Based Classification of Clinical Gene Expression Time Series

Carreiro, André Valério ; Anunciação, Orlando ; Carriço, Jõao André ; Cordeiro Madeira, Sara

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)


Download file

Abstract:
The constant drive towards a more personalized medicine led to an increasing interest in temporal gene expression analyzes. It is now broadly accepted that considering a temporal perpective represents a great advantage to better understand disease progression and treatment results at a molecular level. In this context, biclustering algorithms emerged as an important tool to discover local expression patterns in biomedical applications, and CCC-Biclustering arose as an efficient algorithm relying on the temporal nature of data to identify all maximal temporal patterns in gene expression time series. In this work, CCCBiclustering was integrated in new biclustering-based classifiers for prognostic prediction. As case study we analyzed multiple gene expression time series in order to classify the response of Multiple Sclerosis patients to the standard treatment with Interferon-β, to which nearly half of the patients reveal a negative response. In this scenario, using an effective predictive model of a patient’s response would avoid useless and possibly harmful therapies for the non-responder group. The results revealed interesting potentialities to be further explored in classification problems involving other (clinical) time series.


Institution: Faculty of Technology, Research Groups in Informatics
DDC classification: Data processing, computer science, computer systems

Suggested Citation:
Carreiro, André Valério ; Anunciação, Orlando ; Carriço, Jõao André ; Cordeiro Madeira, Sara  (2011)  Prognostic Prediction through Biclustering-Based Classification of Clinical Gene Expression Time Series. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 8(3), 2011

Online-Journal: http://journal.imbio.de/article.php?aid=175
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2011/5191



 Questions or comments: publikationsdienste.ub@uni-bielefeld.de
 Latest update: 15 Feb 2011
 Legal Notice
OPUS-Logo     OAI compliant      BU Logo
OAI-Logo