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Applying the Tuple Space-Based Approach to the Simulation of the Caspases, an Essential Signalling Pathway

Cárdenas-García, Maura ; González-Pérez, Pedro Pablo

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)


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Abstract:
Apoptotic cell death plays a crucial role in development and homeostasis. This process is driven by mitochondrial permeabilization and activation of caspases. In this paper we adopt a tuple spaces-based modelling and simulation approach, and show how it can be applied to the simulation of this intracellular signalling pathway. Specifically, we are working to explore and to understand the complex interaction patterns of the caspases apoptotic and the mitochondrial role. As a first approximation, using the tuple spaces-based in silico approach, we model and simulate both the extrinsic and intrinsic apoptotic signalling pathways and the interactions between them. During apoptosis, mitochondrial proteins, released from mitochondria to cytosol are decisively involved in the process. If the decision is to die, from this point there is normally no return, cancer cells offer resistance to the mitochondrial induction.


Institution: Faculty of Technology, Research Groups in Informatics
DDC classification: Data processing, computer science, computer systems

Suggested Citation:
Cárdenas-García, Maura ; González-Pérez, Pedro Pablo  (2013)  Applying the Tuple Space-Based Approach to the Simulation of the Caspases, an Essential Signalling Pathway. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 10(1), 2013

Online-Journal: http://journal.imbio.de/article.php?aid=225
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2013/5271



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