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Inter-STOP symbol distances for the identification of coding regions

Bastos, Carlos A. C. ; Afreixo, Vera ; Garcia, Sara P. ; Pinho, Armando J.

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)


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Abstract:
In this study we explore the potential of inter-STOP symbol distances for finding coding regions in DNA sequences. We use the distance between STOP symbols in the DNA sequence and a chi-square statistic to evaluate the nonhomogeneity of the three possible reading frames and the occurrence of one long distance in one of the frames. The results of this exploratory study suggest that inter-STOP symbol distances have strong ability to discriminate coding regions in prokaryotes and simple eukaryotes.


Institution: Faculty of Technology, Research Groups in Informatics
DDC classification: Data processing, computer science, computer systems

Suggested Citation:
Bastos, Carlos A. C. ; Afreixo, Vera ; Garcia, Sara P. ; Pinho, Armando J.  (2013)  Inter-STOP symbol distances for the identification of coding regions. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 10(3): Special Issue: Selected extended papers of the 7th International Conference on Practical Applications of Computational Biology and Bioinformatics, Salamanca, Spain, 2013

Online-Journal: http://journal.imbio.de/article.php?aid=230
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2013/5308



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