Universität Bielefeld Electronic Collections animiertes Foto Universität Bielefeld

Access to the Document



Multi-agent System for Obtaining Relevant Genes in Expression Analysis between Young and Older Women with Triple Negative Breast Cancer

González-Briones, Alfonso ; Ramos, Juan ; De Paz, Juan Francisco ; Corchado, Juan Manuel

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)


Download file

Abstract:
Triple negative breast cancer is an aggressive form of breast cancer. Despite treatment with chemotherapy, relapses are frequent and response to these treatments is not the same in younger women as in older women. Therefore, the identification of genes that cause this difference is required. The identification of therapeutic targets is one of the sought after goals to develop new drugs. Within the range of different hybridization techniques, the developed system uses expression array analysis to measure the expression of the signal levels of thousands of genes in a given sample. Probesets of Gene 1.0 ST GeneChip arrays provide categorical genome transcript coverage, providing a measurement of the expression level of the sample. This paper proposes a multi-agent system to manage information of expression arrays, with the goal of providing an intuitive system that is also extensible to analyze and interpret the results. The roles of agent integrate different types of techniques, statistical and data mining methods that select a set of genes, searching techniques that find pathways in which such genes participate, and an information extraction procedure that applies a CBR system to check if these genes are involved in the disease.


Institution: Faculty of Technology, Research Groups in Informatics
DDC classification: Data processing, computer science, computer systems

Suggested Citation:
González-Briones, Alfonso ; Ramos, Juan ; De Paz, Juan Francisco ; Corchado, Juan Manuel  (2015)  Multi-agent System for Obtaining Relevant Genes in Expression Analysis between Young and Older Women with Triple Negative Breast Cancer. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 12(4): Special Issue: Selected extended papers of the 9th International Conference on Practical Applications of Computational Biology and Bioinformatics, Salamanca, Spain, 2015. Guest editors: Florentino Fdez-Riverola, Juan F. De Paz, Ross Overbeek and Miguel Rocha

Online-Journal: http://journal.imbio.de/article.php?aid=278
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2015/5413



 Questions or comments: publikationsdienste.ub@uni-bielefeld.de
 Latest update: 23 June 2015
 Legal Notice
OPUS-Logo     OAI compliant      BU Logo
OAI-Logo