Universität Bielefeld Electronic Collections animiertes Foto Universität Bielefeld

Zugang zum Dokument



miRquant 2.0: an Expanded Tool for Accurate Annotation and Quantification of MicroRNAs and their isomiRs from Small RNA-Sequencing Data

Kanke, Matthew ; Baran-Gale, Jeanette ; Villanueva, Jonathan ; Sethupathy, Praveen

Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516)



Abstract:
Small non-coding RNAs, in particular microRNAs, are critical for normal physiology and are candidate biomarkers, regulators, and therapeutic targets for a wide variety of diseases. There is an ever-growing interest in the comprehensive and accurate annotation of microRNAs across diverse cell types, conditions, species, and disease states. Highthroughput sequencing technology has emerged as the method of choice for profiling microRNAs. Specialized bioinformatic strategies are required to mine as much meaningful information as possible from the sequencing data to provide a comprehensive view of the microRNA landscape. Here we present miRquant 2.0, an expanded bioinformatics tool for accurate annotation and quantification of microRNAs and their isoforms (termed isomiRs) from small RNA-sequencing data. We anticipate that miRquant 2.0 will be useful for researchers interested not only in quantifying known microRNAs but also mining the rich well of additional information embedded in small RNA-sequencing data.


Beteiligte Einrichtung: Technische Fakultät, Arbeitsgruppen der Informatik
DDC-Sachgruppe: Datenverarbeitung, Informatik

Zitat-Vorschlag:
Kanke, Matthew ; Baran-Gale, Jeanette ; Villanueva, Jonathan ; Sethupathy, Praveen  (2016)  miRquant 2.0: an Expanded Tool for Accurate Annotation and Quantification of MicroRNAs and their isomiRs from Small RNA-Sequencing Data. Journal of Integrative Bioinformatics - JIB (ISSN 1613-4516), 13(5): Special Issue: Computational miRNomics, 2016

Online-Journal: http://journal.imbio.de/article.php?aid=307
URL: http://biecoll.ub.uni-bielefeld.de/volltexte/2017/5445



 Fragen und Anregungen an: publikationsdienste.ub@uni-bielefeld.de
 Letzte Änderung: 23.06.2015
 Impressum
OPUS-Logo     OAI-zertifiziert      Universitätsbibliothek Bielefeld
OAI-Logo